Spring - Keystone

<h1><strong>3-MONTH SUPPLY</strong></h1> <p><strong>Berberine ES:</strong><br data-mce-fragment="1"></p> <p>5× the Bioavailability of Berberine*<br data-mce-fragment="1">Supports Enhanced Berberine Activity*<br data-mce-fragment="1">Supports Healthy Blood Glucose Metabolism<br data-mce-fragment="1"></p> <p>Berberine ES features dihydroberberine (DHB), a highly bioavailable metabolite of berberine with demonstrated benefits for blood glucose metabolism. Berberine naturally occurs in several plant species used extensively in traditional Ayurvedic and Chinese herbal practices; DHB is the natural bioactive form of berberine.*<br data-mce-fragment="1"><br data-mce-fragment="1"><strong>Slim Biotic:</strong><br data-mce-fragment="1"><br data-mce-fragment="1">Slim Biotic for Body Composition Support*<br data-mce-fragment="1">Supports Healthy Weight Management*<br data-mce-fragment="1">Promotes Gut Barrier Function*<br data-mce-fragment="1">Promotes Intake of Less Calories*<br data-mce-fragment="1">Supports Reduction of Body Fat Mass*<br data-mce-fragment="1"></p> <p>Slim Biotic features vegetarian, gluten- and dairy-free, patented HOWARU® Shape Bifidobacterium animalis subsplactis B420. This probiotic strain has been proven safe, effective, and well-tolerated. It has been shown to assist with healthy body composition by improving gut barrier function, supporting the reduction of body fat mass, and promoting less calorie consumption.*<br data-mce-fragment="1"><br data-mce-fragment="1"><strong>Fiber Lean:</strong><br data-mce-fragment="1"></p> <p>100% Natural and Soluble Propolmannan Fiber<br data-mce-fragment="1"><br data-mce-fragment="1">Supports Satiety*<br data-mce-fragment="1">Supports Weight Control*<br data-mce-fragment="1">Supports Glucose Metabolism*<br data-mce-fragment="1">Supports Cholesterol Metabolism*<br data-mce-fragment="1">Supports Healthy Bowel Movements* Serves as a Prebiotic for Intestinal Bacteria*<br data-mce-fragment="1"></p> <p>Fiber Lean features Shimizu Propol® A propolmannan—a highly pure, natural soluble fiber. Propol A is created from Amorphophallus konjac-derived glucomannan using proprietary processing techniques. This fiber has been studied for its viscosity and for its stability through the digestive tract; and studies support its health effects, such as on satiety, weight control, glucose and lipid metabolism, and bowel regularity.*</p>

<div data-mce-fragment="1"><strong>Key Biotic #30</strong></div> <div data-mce-fragment="1"><span>Going beyond the threshold of traditional probiotic support, high-dose probiotics influence gut health and immunity in ways lower-dose probiotics cannot. Shown to activate over 1,700 genes involved in immune and inflammatory signaling, high-dose probiotics improve immune function, maintain a healthy gut-immune barrier, and maintain normal inflammatory balance. Each Key Biotic 100 capsule provides six proven probiotic strains chosen for their ability to survive the harsh GI environment to deliver superior results.</span></div> <br> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"><strong>Optimal Omegas #60</strong></div> <div data-mce-fragment="1"><span>Provides 820 mg of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as 50 mg of docosapentaemoic acid (DPA) per soft gel as re-esterified triglycerides, the preferred form with superior absorption. Vitamin E (as mixed tocopherols) and rosemary extract are used to ensure maximum purity and freshness.</span></div> <br> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"><strong>Mito Fuel #120</strong></div> <div data-mce-fragment="1">Scientifically formulated, based on published research, to boost mitochondrial reserves and jump-start cellular energy production. Mito Fuel includes the powerful antioxidant trio of alpha lipoic acid, N-acetyl cysteine and acetyl L-carnitine shown to increase energy production and at the same time, recharge the primary cellular antioxidant pools of vitamin E, C and glutathione. Mito Fuel also includes key micronutrients and phytonutrients including green tea, broccoli seed extract and resveratrol to protect the mitochondria and continually renew the cycle of energy production.</div> <br> <div data-mce-fragment="1"></div> <div data-mce-fragment="1"></div> <div data-mce-fragment="1"></div> <div data-mce-fragment="1"></div> <div data-mce-fragment="1"><strong>Essential Mag #60</strong></div> <div data-mce-fragment="1"><span>Provides three unique forms of highly-absorbed magnesium to ensure maximum absorption of this important macromineral. Most magnesium supplements use only a single source of magnesium, which can easily overwhelm a single pathway of absorption and limit uptake. Essential Mag takes advantage of three unique pathways of absorption by providing magnesium as di-magnesium malate, magnesium citrate and magnesium glycinate for enhanced absorption, improved utilization and gastrointestinal (GI) comfort. Some individuals, who take other forms of magnesium supplements, often experience GI side effects, including gas, bloating, diarrhea, constipation or a combination of these symptoms. The forms of magnesium used in Essential Mag preserve GI comfort while maximizing absorption and restoring magnesium levels in the body.</span></div> <br> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"><span></span></div> <div data-mce-fragment="1"> <br data-mce-fragment="1" clear="all"> <div data-mce-fragment="1"> <div data-mce-fragment="1" dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"> <div data-mce-fragment="1" dir="ltr"> <div data-mce-fragment="1"><strong><span data-mce-fragment="1" face="arial, sans-serif" style="font-family: arial, sans-serif;" data-mce-style="font-family: arial, sans-serif;">CoEnzyme Q10/100mg  #30</span></strong></div> <div data-mce-fragment="1"><span data-mce-fragment="1" face="arial, sans-serif" style="font-family: arial, sans-serif;" data-mce-style="font-family: arial, sans-serif;"><span>Co-Enzyme Q10 softgels contain pure co-enzyme Q10 (ubiquinone). Co-enzyme Q10 is solubilized in a base of rice bran oil and vitamin E to enhance absorption of coenzyme Q10.</span></span></div> </div> </div> </div> </div>

<p> </p> <p data-mce-fragment="1">Dehydroepiandrosterone (DHEA) is a steroid hormone precursor that helps maintain healthy hormone levels and helps support the stress response system. DHEA functions as the counterpart to the stress hormone cortisol. Maintaining healthy DHEA levels is crucial for balancing the catabolic effects of cortisol. </p> <p data-mce-fragment="1">DHEA and its sulfate, DHEAs, are the most abundant steroid hormones in the human body and can be found in blood, saliva, urine and cerebrospinal fluid (CSF). DHEA serves as a “buffer” reservoir to be used for the intracellular synthesis of various estrogens and androgens throughout the human body. DHEA production peaks during the second decade of life. Beginning in the early 30s, DHEA levels typically decline by 10% per decade. In addition to the normal decline associated with aging, other possible causes of a decline in DHEA production include inflammation, blood sugar imbalances and long-term stress.<br data-mce-fragment="1"></p> <p data-mce-fragment="1"><strong data-mce-fragment="1">Suggested Use:</strong></p> <p data-mce-fragment="1">1 tablet per day or as recommended by your health care professional.</p> <p data-mce-fragment="1"> </p> <p data-mce-fragment="1">Compare to Ortho Molecular DHEA 5mg</p>

<meta charset="UTF-8"> <div class="" data-mce-fragment="1"> <div class="product-content-tab" data-mce-fragment="1"> <p data-mce-fragment="1">Traditionally, colostrum is considered the “first food” of newborns because it is easily digestible and enhances the immune system. An optimally functioning immune system prevents unwanted toxins and molecules from disturbing the body’s natural homeostasis. Colostrum naturally includes immune factors, amino acids, nucleotides and growth factors which provide several benefits to human immune health by functioning against microorganisms. There are five main immunoglobulins, but the most common is IgG, which accounts for 75-80% of all serum antibodies in the body. IgG plays a major role in immune system function, as it defends the body against foreign substances.<br data-mce-fragment="1"></p> <p data-mce-fragment="1"><span data-mce-fragment="1">GI Nourish Powder’s pure and high-concentration formula provides improved immune modulation and strengthens the gut-immune barrier. Consistency in potency and purity of colostrum extracts is a primary concern for clinicians; advanced filtration and purification techniques make IgG Protect Powder a superior clinical tool. GI Nourish Powder provides 2,000 mg of IgG and 4 g of protein per serving.</span><br data-mce-fragment="1"></p> <p data-mce-fragment="1"><strong data-mce-fragment="1">Suggested Use:</strong></p> <p data-mce-fragment="1">1 or more scoops per day in 4 ounces of water or the beverage of your choice or as recommended by your health care professional.</p> </div> </div> <button class="product-content-btn" data-mce-fragment="1"></button>

<h3><strong><span class="WdYUQQ text-decoration-none text-strikethrough-none" data-mce-fragment="1">BUNDLE 1</span></strong></h3> <p><strong><span class="WdYUQQ text-decoration-none text-strikethrough-none" data-mce-fragment="1">Magtality</span>:</strong><br data-mce-fragment="1"><br data-mce-fragment="1"><span data-mce-fragment="1">Magtality features magnesium L-threonate (as Magtein®), the only form of magnesium known to cross the blood-brain barrier. Complemented by highly absorbable Albion® di-magnesium malate and TRAACS® magnesium lysinate glycinate chelate, this formula is designed to boost the brain’s magnesium level. Magnesium is vital to supporting brain</span><br data-mce-fragment="1"><span data-mce-fragment="1">health and promoting healthy nervous system functions.*</span><br data-mce-fragment="1"><strong></strong></p> <p><strong><span class="WdYUQQ text-decoration-none text-strikethrough-none" data-mce-fragment="1">Lights Out</span>:</strong><br data-mce-fragment="1"><br data-mce-fragment="1"><span data-mce-fragment="1">Lights Out is a blend of botanicals, nutrients, and neurotransmitter precursors designed to support quality, restful sleep. By providing nutritional support for calm brain activity, Lights Out helps promote the body’s natural ability to fall asleep and stay asleep.* Key ingredients include botanicals that support nervous system function, PharmaGABA® (a proprietary form of gamma-aminobutyric acid [GABA]), L-theanine, melatonin, 5-hydroxytryptophan (5-HTP), and pyridoxal-5-phosphate (the activated form of vitamin B6).*</span><br data-mce-fragment="1"><br></p> <h3><strong>BUNDLE 2</strong></h3> <p><strong><span class="WdYUQQ text-decoration-none text-strikethrough-none" data-mce-fragment="1">Magtality</span>:</strong></p> <p>Supports Healthy Brain Magnesium Levels*<br></p> <p>Supports Healthy Synapse Number and Function*<br></p> <p>Supports Cognitive Health*<br></p> <p>Supports Stress Management, Sleep Quality, and a Healthy Mood*<br></p> <p>Helps Ensure an Optimal Magnesium Intake for Overall Health*</p> <p>Magtality features magnesium L-threonate (as Magtein®), the only form of magnesium known to cross the blood-brain barrier. Complemented by highly absorbable Albion® di-magnesium malate and TRAACS® magnesium lysinate glycinate chelate, this formula is designed to boost the brain’s magnesium level. Magnesium is vital to supporting brain<br data-mce-fragment="1">health and promoting healthy nervous system functions.</p> <p><strong><span class="WdYUQQ text-decoration-none text-strikethrough-none" data-mce-fragment="1">Lights Out</span>:</strong><br data-mce-fragment="1"><br data-mce-fragment="1"><span data-mce-fragment="1">Lights Out is a blend of botanicals, nutrients, and neurotransmitter precursors designed to support quality, restful sleep. By providing nutritional support for calm brain activity, Lights Out helps promote the body’s natural ability to fall asleep and stay asleep.* Key ingredients include botanicals that support nervous system function, PharmaGABA® (a proprietary form of gamma-aminobutyric acid [GABA]), L-theanine, melatonin, 5-hydroxytryptophan (5-HTP), and pyridoxal-5-phosphate (the activated form of vitamin B6).</span></p>

<p>Berberine is a plant alkaloid derived from several different plant species customarily used in Ayurveda and traditional Chinese medicine for various therapeutic applications. Modern clinical use and published in vivo, in vitro, and animal research studies<br>demonstrate that the berberine metabolite dihydroberberine (DHB) is more bioavailable than berberine and offers enhanced support for healthy blood glucose metabolism.<br></p> <p>Although the mechanisms underlying the beneficial effects of berberine are not entirely clear, it is hypothesized that the modulation of gut microbes may be one mechanism by which berberine affects blood glucose metabolism. Results from animal and in<br>vitro studies suggest that berberine moderates glucose and lipid metabolism through a multi-pathway mechanism, including the adenosine monophosphate–activated protein kinase (AMPK), c-Jun N-terminal kinase (JNK), and peroxisome proliferator-activated<br>receptor (PPAR)-alpha pathways. Separate research on AMPK reports activating the AMPK pathway stimulates glucose uptake and fat oxidation while suppressing lipogenesis and gluconeogenesis. Berberine is also believed to be involved in the regulation of pancreatic beta cell function, and it has been observed to inhibit the expression of disaccharidases in the duodenum, resulting in less glucose formation from carbohydrate digestion.<br></p> <p>Increasing evidence indicates that gut microbiota are also crucial mediators that regulate berberine’s pharmacokinetic and biological effects. Berberine induces compositional alterations in gut microbiota and regulates gut microbe–dependent metabolites, factors<br>that contribute to its biological effects on lipid and glucose metabolism. Additionally, gut microbiota reduce berberine to DHB, its intestine-absorbable form, which then oxidizes back to berberine after it has been absorbed into intestinal tissues and entered the blood.<br></p> <p>Berberine absorption across the intestinal epithelia is suggested to be compromised because of its “flat” chemical configuration. Berberine displays poor bioavailability and increased potential for GI distress at the oral doses required to improve biomarkers associated with glucose homeostasis. The structure of the DHB derivative of berberine is comparably open, making it more amenable to uptake. To further explore the absorbability of berberine and DHB, researchers investigated the mechanism of action by which AMPK is activated and if using DHB at lower doses than berberine could potentially improve the effect on adiposity and glucose metabolism in rodents fed a high-fat diet. Berberine had to be administered at a nearly 5-fold increased dose of 560 mg/kg/d to establish the same effects demonstrated by DHB at 100 mg/kg/d. The rodents treated with the substantially lower dose of DHB showed markedly reduced adiposity and improved glucose tolerance. Additionally, insulin sensitivity was increased in the DHB-treated animals. These results led researchers to suggest that the difference in effects between berberine and DHB is due to the enhanced bioavailability of DHB. The findings of this study indicate that DHB delivers the beneficial metabolic effects of berberine in a more absorbable form and at a lower dose.<br></p> <p>A small, randomized, double-blind, crossover pilot study (N = 5) investigated the absorption kinetics and compared the dosing of berberine and DHB required to achieve peak plasma concentrations. Subjects completed a 4-dose protocol of placebo, 500 mg of berberine, 200 mg of DHB, and 100 mg of DHB. Participants ingested the first 3 doses with breakfast, lunch, and dinner, followed by an overnight fast, then a standardized test meal accompanied by dose 4. Blood samples were collected at regular intervals after ingestion and analyzed for berberine, glucose, and insulin. Four doses of 100 mg and 200 mg of DHB produced significantly greater concentrations of plasma berberine across the 2-hour measurement window than a 500-mg dose of berberine or placebo.<br>Results suggest that irrespective of dose, DHB achieves a greater area under the curve and peak berberine concentrations when compared with oral ingestion of berberine.<br></p> <p>Keystone Compounding Pharmacy’s Berberine ES contains DHB originating from berberine sourced from Berberis aristata and naturally extracted through an enzymatic process similar to that which occurs in the human gut. With a 5-fold relative increase in<br>absorption rate, supplemental DHB at much lower doses than berberine has comparable beneficial metabolic effects.</p> <p><strong>Suggested Use:</strong></p> <p>1 capsule once or twice daily, or use as directed by your healthcare professional.</p>

<p>While a healthy diet and exercise are paramount to good health and maintaining healthy body composition, adding supplementary soluble fiber offers additional benefits. When selecting fiber, there are many aspects to review. Each fiber is unique in origin, purity, viscosity, and overall stability once ingested. In fact, even one type of fiber can vary greatly in quality. Amorphophallus konjac, a tuberous plant, is a rich source of the<br>soluble fiber glucomannan. This fiber has an exceptional ability to absorb water and is one of the most viscous dietary fibers known.<br></p> <p><strong>Not All Glucomannans Are Created Equal</strong><br>There are many aspects of glucomannan that affect end-product quality: the species of konjac used, the harvesting location, the time of harvesting, the production process, impurities (e.g., sulfites), viscosity, the response of the viscosity to different pH levels and temperatures, and hydration speed. For these reasons, finding the material with the most manufacturing and processing experience and scientific research behind it is important.<br></p> <p><strong>Propol® A Propolmannan</strong><br>Shimizu Chemical Corporation is a pioneer in the world of dietary fiber and its health benefits. Using its vast knowledge—over 300 years of processing raw material (Japanese Amorphorphallus konjac species) and extracting glucomannan—it has developed Propol A propolmannan, a highly purified glucomannan. Shimizu’s unique and proprietary three-stage purification process is carried out in large-scale extraction plants and involves pulverizing the Amorphophallus tubers, collecting mannan-glucose particles, and polishing the particles in order to dislodge and extract noxious materials that adhere to them. With the use of cutting-edge technology, Propol A has been reduced to a special particle size that maximizes density while remaining in desirable viscous form. This process yields a pure, refined, high-performance Amorphophallus propolmannan that improves product solubility, stability, and overall functionality.<br></p> <p><strong>Viscosity, Stability Through the Digestive Tract</strong><br>Viscosity is a physicochemical property of soluble fiber that reflects the fiber’s ability to thicken as it mixes with fluid. Viscosity is a recognized factor affecting physiological responses to soluble fiber. Propol A features an extremely high viscosity (100,000 mPa·s), which is thought to contribute to its health benefits. Furthermore, as a benefit of its unique processing, Propol A remains intact in the digestive tract—another key factor in fiber functionality. Viscosity and stability, taken together, produce a highly effective material that, once in the digestive tract, attracts water and forms a viscous gel-like substance that slows digestion, delays the emptying of food from the stomach into the small intestine, slows down the influx of carbohydrates and fats into the bloodstream, binds to bile acids, and impedes dietary fat absorption.<br></p> <p><strong>Satiety and Weight Control</strong><br>Soluble fiber is known to act as a bulking agent in the stomach and intestine, which creates the signals of fullness and causes individuals to eat less. Studies suggest that glucomannan supplementation significantly reduces weight at doses of 3 g/d to 4 g/d when compared to placebo. In a randomized, double-blind, placebo-controlled study, the effects of 3 g/d of Propol (1 g 30-60 minutes prior to each meal) combined with 300<br>mg/d of calcium were studied. When dosing compliant and non-complaint subgroups were analyzed, the results indicated that compliant subjects experienced a significant reduction in scale weight, body fat percentage, and fat mass without a loss of fat-free mass or bone density. In another study, the mean weight loss for the glucomannan group was 5.5 lbs in eight weeks, while subjects in the placebo group gained 1.5 lbs.<br></p> <p><strong>Glucose and Lipid Metabolism</strong><br>Soluble fiber slows the absorption of carbohydrates, which influences the release of insulin and the rate of fat storage. Glucomannan studies have not only demonstrated a positive impact on postprandial glucose handling and glucose metabolism but also on cholesterol metabolism. This latter effect is thought to result from the fact that soluble fiber reduces fat and cholesterol absorption and carries bile out of the intestines.<br>When fewer bile acids are available, the body draws cholesterol from the bloodstream to make more.<br></p> <p><strong>Healthy Bowel Function, Prebiotic</strong><br>Glucomannan not only allows more water to remain in the stool, thereby making waste softer, larger, and easier to pass through the intestines, but it is also an excellent prebiotic. In a placebo-controlled, randomized, parallel, double-blind, crossover trial, doses of 3 g/d and 4 g/d of glucomannan had a positive impact on intestinal habit (i.e., daily and weekly evacuations) and stool characteristics when compared to placebo.<br> Glucomannan has also been shown to reduce mouth-to-cecum transit time compared to placebo. In other research, glucomannan improved defecation frequency, eased bowel movement, increased the fecal concentration of lactobacilli as well as the daily output of bifidobacteria, lactobacilli, and total bacteria. In addition, fermentation of glucomannan resulted in greater fecal acetate, propionate, and i-butyrate concentrations<br>and lower fecal pH.</p> <p><strong>Directions:</strong></p> <p>Mix one to two scoops (1.6-3.2 g) in 8-12 oz of water or other non- alcoholic beverage and consume once per day, or mix one scoop as directed and consume 30 to 60 minutes before each of your two biggest meals, or use as directed by your healthcare professional.</p>

<strong>Adipogen Pro:</strong><br data-mce-fragment="1"><br data-mce-fragment="1">Targeting Fat Cells*<br data-mce-fragment="1">Affects Adipogenesis and the Genetic Expression of Adipogenic Marker Genes in Multipotent Cells*<br data-mce-fragment="1">Affects Synovial Fluid and Serum Leptin Levels*<br data-mce-fragment="1">Supports Weight Loss*<br data-mce-fragment="1"><br data-mce-fragment="1">Adipogen Pro represents an advanced, science-based strategy for positively affecting leptin levels. Leptin is a fat-cell derived hormone that is elevated in some individuals. Healthy leptin activity helps balance energy intake and expenditure by influencing appetite, food cravings, and metabolism.*

<div class="RenderCleanHtml__StyledRenderCleanHtml-sc-ddx8t7-0 ItemDetailsRenderCleanHtml-sc-flcma9-0 hBnQJW dJxdLa" data-mce-fragment="1"> <p data-mce-fragment="1">Lights Out is a blend of botanicals, nutrients, and neurotransmitter precursors designed to support quality, restful sleep. By providing nutritional support for calm brain activity, Lights Out helps promote the body’s natural ability to fall asleep and stay asleep.* Key ingredients include botanicals that support nervous system function, PharmaGABA® (a proprietary form of gamma-aminobutyric acid [GABA]), L-theanine, melatonin, 5-hydroxytryptophan (5-HTP), and pyridoxal-5-phosphate (the activated form of vitamin B6).*</p> <p data-mce-fragment="1"><strong data-mce-fragment="1">Recommended Use:<span data-mce-fragment="1"> </span></strong>Take 2 capsules per day 30 to 60 minutes before bedtime or as directed by your health-care practitioner.</p> <p data-mce-fragment="1"> </p> <p data-mce-fragment="1">Ingredient Highlights</p> <p data-mce-fragment="1"><strong> Melatonin</strong> is a multifunctional neuroendocrine hormone whose main role lies in its involvement in the control of the circadian biological rhythms. Melatonin mediates the body’s response to variations of natural light availability from indoor/outdoor exposure or to the change of seasons (winter to summer). The visual perception of darkness tells the brain to make melatonin so the body can prepare for sleep mode. The production of melatonin normally peaks at night and is instrumental for maintaining quality sleep patterns.1,2 Melatonin production declines significantly with age, often causing sleep difficulties associated with aging.3‑6 Evidence from meta‑analyses and systematic reviews suggests that melatonin (dosages ranging between 2 g and 10 g) has positive effects on sleep quality by reducing sleep onset latency and increasing total sleep time in individuals with primary and secondary sleep disorders.7‑9 Exogenous melatonin has also been shown to promote improved sleep quality for postmenopausal women with sleep disturbances. Results from a systematic review and network meta‑analysis suggest that melatonin supplementation in the range of 0.5 mg to 12 mg (alone or in combination with other complementary and alternative therapies) promoted the amelioration of sleep onset latency and daytime sleepiness in both adults and pediatric populations with insomnia.</p> <p data-mce-fragment="1"><strong> 5‑HTP</strong> works in conjunction with melatonin, as a precursor to the serotonin biosynthesis, which can further support endogenous melatonin production during the night to help facilitate staying asleep. In the brain, serotonin is involved in mood modulation, cognition, learning, memory, reward, appetite, sleep, and more.12 Insufficient serotonin can contribute to impaired or reduced melatonin synthesis and cause insomnia. Therefore, 5‑HTP supplementation may help promote a balanced sleep/wake cycle by supporting serotonin synthesis.</p> <p data-mce-fragment="1"><strong>Vitamin B6 (as Pyridoxal‑5‑Phosphate [P5P])</strong> acts as a coenzyme in the synthesis of neurotransmitters including serotonin. The conversion of tryptophan into 5‑HTP and of 5‑HTP into serotonin requires P5P, which is derived from vitamin B6. P5P also acts a coenzyme in the synthesis of dopamine, norepinephrine, and GABA.14 Having adequate levels of vitamin B6 supports serotonin synthesis and melatonin production, as it is a precursor.*</p> <p data-mce-fragment="1"><strong>Gamma‑aminobutyric acid (as PharmaGABA®)</strong> is a naturally occurring amino acid in the brain and a major inhibitory neurotransmitter in the central nervous system. GABA serves as a critical calming agent for the body, helping to support mild or occasional stress and anxiety.* The GABA in PharmaGABA® is made through the fermentation of the amino acid glutamic acid (glutamate) by the beneficial bacteria Lactobacillus hilgardii. As an inhibitory neurotransmitter, GABA inhibits nerve impulses, slowing down the activity of nerve cells and preventing them from overfiring. Upon binding with the GABA receptors, a negative change in the transmembrane potential occurs, which leads to hyperpolarization and a decrease in the excitability of neurons. . In stressful situations, GABA levels in the body can decrease, leading to an imbalance in the excitatory/inhibitory system. In a study on humans, prefrontal brain GABA levels decreased by 18% after acute psychological stress.15 Studies have shown that low GABA levels have been associated with poor sleep quality, especially in patients with post‑traumatic stress disorder.16 GABA can be calming, which may help to benefit mood, sleep, and the response to stress. In a study of 13 subjects, alpha and beta brain waves were evaluated by electroencephalogram after oral intake of GABA. Alpha waves are produced during meditation and any time the body is relaxed and alert. Beta waves, on the other hand, are seen in situations of high stress where focus and concentration are difficult. Results after 1 hour showed that GABA increased the production of alpha waves while decreasing beta waves, indicating that GABA may help induce relaxation and reduce anxiety.17 A systematic review found promising evidence for potential benefits of oral GABA consumption on stress and sleep, especially on inducing and improving early stages of sleep.</p> <p data-mce-fragment="1"><strong> L‑Theanine</strong> is a nonprotein amino acid found in green tea with anxiolytic and stress‑reducing effects that have been shown to promote relaxation and support sleep.* The structure of L‑theanine is analogous to glutamate, so it has the potential to bind to glutamate receptors and hinder glutamatergic activation and associated neuroexcitatory effects, thereby supporting a healthy response to stress.*19‑23 It may also decrease glutamate release in the pre‑synaptic terminals since glutamatergic transmission is affected by L‑theanine–mediated inhibition of glutamine uptake to suppress the conversion of glutamine to glutamate.20‑23 Research illustrates that L‑theanine may increase alpha wave transmission, which is more predominant in restful and relaxation situations. L‑theanine may also promote the release of GABA, which regulates serotonin and dopamine levels.20‑22,24 Studies have found that L‑theanine also lowers cortisol production. 20‑22,24 Clinical studies found that supplementing with L‑theanine is beneficial to support the treatment of occasional stress, anxiety, and depression, and to enhance sleep quality and cognitive function.20,21,24‑27</p> <p data-mce-fragment="1"><strong>Calming Herbal Blend</strong> Each 2‑capsule serving of Insomnitol™ contains 400 mg of valerian root (Valeriana officinalis) standardized to contain 0.8% valerenic acid, 200 mg of passion flower (Passiflora incarnata) standardized to contain 3.5% flavonoids, 200 mg of lemon balm (Melissa officinalis) standardized to have 3% rosmarinic acid, and 200 mg chamomile (Matricaria chamomilla). All of these ingredients are considered nervine botanicals that have been traditionally used as a sleep aid due to their relaxant properties and ability to help promote quality sleep, without causing morning drowsiness.28 The sedative and sleep‑promoting properties of valerian, passion flower, and lemon balm may be influenced by the interaction of the volatile oils and bioactive constituents with GABA receptors, modulating GABAergic signaling.29 Although research on valerian root is inconsistent and more clinical studies are needed, a systematic review and meta‑analysis of 60 studies suggest that it may be an effective herb to help promote sleep.30 In vitro and clinical studies showed that valerian root may help reduce sleep latency and improved subjective sleep measures.29 In vitro and animal models found that passion flower reduced sleep latency and increased sleep duration, and lemon balm improved overall sleep quality by decreasing GABA transaminase activity, which metabolizes GABA.29 In a clinical trial (n = 60) of elderly people, the group receiving 200 mg of chamomile extract twice daily for 28 days showed significantly improved sleep quality compared to the control group.31</p> <p data-mce-fragment="1"> </p> <p data-mce-fragment="1"><span class="noindent" data-mce-fragment="1"><strong data-mce-fragment="1">* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.</strong></span></p> </div> <div class="robotoCondensed ItemAdvisorTags__StyledItemAdvisorTags-sc-19n4u7r-0 hThqER" data-mce-fragment="1"> <span class="advisor-tag-element" data-mce-fragment="1">GLUTEN FREE </span><span class="advisor-tag-element" data-mce-fragment="1">DAIRY FREE </span><span class="advisor-tag-element" data-mce-fragment="1">SOY FREE </span><span class="advisor-tag-element" data-mce-fragment="1">VEGETARIAN </span><span class="advisor-tag-element" data-mce-fragment="1">NON-GMO </span><span class="advisor-tag-element" data-mce-fragment="1">VEGAN</span> </div>

<p><strong>Description:</strong><br>Ashwagandha 35 features Shoden®, a purified extract of the leaves and roots of the ashwagandha plant that has been standardized to an industry-leading concentration of 35% withanolide glycosides. Shoden has been researched for its effects in helping the body adapt to physical and mental stressors and supporting the restoration of sleep quality.*</p> <p> </p> <div class="fact_header"> <h3>Supplement Facts</h3> <p class="servings">Serving Size: 2 Capsules<br>Servings Per Container: 30<br></p> </div> <div class="fact_body"> <table cellpadding="0" cellspacing="0"> <tbody> <tr> <th></th> <th>AMOUNT PER SERVING</th> <th>% DAILY VALUE</th> </tr> <tr> <td> <div> <p>Ashwagandha Extract (<i>Withania somnifera</i>)(roots and leaves) (35% withanolide glycosides)^S1</p> </div> </td> <td>240 mg</td> <td>**</td> </tr> </tbody> </table> </div> <div class="fact_footer">** Daily Value not established.</div>

<p>Iron is one of the most abundant minerals on earth. It is essential to the majority of life forms, especially human physiology. Iron supports prenatal and cognitive health, as well as energy balance.</p> <p>Iron is an integral component of the proteins involved in oxygen transport and storage: hemoglobin, myoglobin and ferritin. Iron, as part of the protein hemoglobin, carries oxygen from the lungs to various parts of the body. Hemoglobin accounts for nearly two-thirds of the iron found in the body, and carries essential oxygen to tissues and organs. Approximately one-sixth of the bodys iron is stored as ferritin for use when dietary intake is not sufficient.</p> <p>Iron must be maintained at balanced levels within the body too much can cause toxicity and too little may lead to impairment of optimal health outcomes. Iron has to be carefully absorbed by the body. Interference can easily occur, making adequate consumption through diet and supplementation imperative to achieving a healthy balance.</p> <p>Gentle Iron provides 29 mg of elemental iron per serving, ideally formulated using the amino acid chelate form of iron (ferrous bisglycinate) for enhanced absorption, optimal utilization and gastrointestinal (GI) comfort. Some individuals, who take other forms of iron supplements, may experience GI side effects, including gas, bloating, constipation or a combination of these symptoms. Supplementing the right form of iron can be key to maintaining healthy levels within the body and compliance to a supplement regimen.</p> <p><strong>Suggested Use:</strong></p> <p>1 capsule per day or as recommended by your health care professional</p>

<p>GI Nourish is a highly concentrated (40%) immunoglobulin G (IgG) formula that provides essential nutrition for improved immune health. GI Nourish's pure and high-concentration formula provides improved immune modulation and strengthens the gut-immune barrier. Consistency in potency and purity of colostrum extracts is a primary concern for clinicians; advanced filtration and purification techniques make GI Nourish a superior clinical tool. GI Nourish provides 1,000 mg of IgG and 2 g of protein per serving.</p> <p><strong>Suggested Use:</strong></p> <p>4 capsules per day or as recommended by your health care professional.</p> <p> </p> <p>Compare to Ortho Molecular's IgG Protect</p>

<p>A powerful blend of eight synergistic ingredients designed to help support male health.* Additionally, the select ingredients in this formula have been proven clinically effective in supporting sexual health and energy as well as supporting healthy cortisol and dopamine levels.*</p> <p> </p> <p>*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.</p>

<p>Over time lifestyle factors can cause reduced elasticity in cartilage, tendons, ligaments and skin. This not only leads to wrinkles and decreased dermal matrix, but to soft tissue and joint discomfort. FORTIGEL® has been shown in human studies to stimulate collagen regeneration, type II collagen and aggrecan, which all help to maintain healthy connective tissue. Most therapies simply block joint pain and connective tissue discomfort, and in doing so inhibit the regeneration and elongation of specific precursors, such as polysaccharides, and deplete nutrients such as vitamin C and magnesium that maintain joint and connective tissue health. FORTIGEL®, TendoActive® and Mobilee® protect and preserve cartilage, tendons, ligaments, intervertebral discs, and fascia. These patented ingredients support the natural healing process and maintain the structure of connective tissues.</p> <p><b>Suggested Use:</b>1 scoop (7.6 grams) in 8 oz of water or the beverage of your choice per day or as recommended by your health care professional. Can also be added to food and baking products.</p>

<p>Hormones (especially estrogen) are critically important in human development and tissue repair. However, estrogen’s proliferative effects must be balanced and controlled for optimal health. Therefore, to ensure proper hormonal balance, estrogen synthesis and detoxification should be supported. Estrogen has several downstream metabolites, of which some are beneficial while others possess potentially harmful biological activity. By keeping hormones in balance and ensuring the body can process estrogen properly, cruciferous vegetable metabolites (i.e., I3C and DIM) work together to maintain cellular health.</p> <p><strong>Suggested Use:</strong></p> <p>1 capsule per day or as recommended by your health care professional</p>

<p>Going beyond the threshold of traditional probiotic support, high-dose probiotics influence gut health and immunity in ways lower-dose probiotics cannot. Shown to activate over 1,700 genes involved in immune and inflammatory signaling, high-dose probiotics improve immune function, maintain a healthy gut-immune barrier, and maintain normal inflammatory balance. Each Key Biotic 100 capsule provides six proven probiotic strains chosen for their ability to survive the harsh GI environment to deliver superior results.</p> <p><strong>Suggested Use:</strong></p> <p>1 capsule per day or as recommended by your health care professional.</p>

<p>Key Immune is a targeted blend of nutrients designed to provide a broad-spectrum support to the body’s immune reserves. The formula includes quercetin, a powerful bioflavonoid that aids in supporting the immune system. Vitamin C and N-acetyl cysteine are potent antioxidants that promote respiratory function and support the function of quercetin. Vitamin D and zinc are important micronutrients needed to create a robust immune reserve. This powerful combination works to promote healthy respiratory and immune function.</p> <p><strong>Suggested Use:</strong></p> <p>2 capsules a day or as recommended by your health care professional.</p> <p> </p> <p>Compare to OrthoMolecular's OrthoMune</p>

<style type="text/css" data-mce-fragment="1"><!-- td {border: 1px solid #cccccc;}br {mso-data-placement:same-cell;} --></style> <p><span data-sheets-value='{"1":2,"2":"L-Theanine is a naturally occurring, unique amino acid found in green tea leaves. NuMedica’s L-Theanine is Suntheanine®, the most respected source and the one which has been used in scientific studies. L-Theanine may promote a sense of relaxation without causing drowsiness.* It has also been found to promote healthy cellular function and reduce feelings of stress and anxiety.* Relaxation support is enhanced by the synergistic effects of the added chamomile extract.*"}' data-sheets-userformat='{"2":12796,"5":{"1":[{"1":2,"2":0,"5":{"1":2,"2":10066329}},{"1":0,"2":0,"3":3},{"1":1,"2":0,"4":1}]},"6":{"1":[{"1":2,"2":0,"5":{"1":2,"2":10066329}},{"1":0,"2":0,"3":3},{"1":1,"2":0,"4":1}]},"7":{"1":[{"1":2,"2":0,"5":{"1":2,"2":10066329}},{"1":0,"2":0,"3":3},{"1":1,"2":0,"4":1}]},"8":{"1":[{"1":2,"2":0,"5":{"1":2,"2":10066329}},{"1":0,"2":0,"3":3},{"1":1,"2":0,"4":1}]},"9":0,"10":2,"11":4,"15":"Arial","16":9}' data-mce-fragment="1">L-Theanine is a naturally occurring, unique amino acid found in green tea leaves. Keystone’s L-Theanine is Suntheanine®, the most respected source and the one which has been used in scientific studies. </span></p> <p><span data-sheets-value='{"1":2,"2":"L-Theanine is a naturally occurring, unique amino acid found in green tea leaves. NuMedica’s L-Theanine is Suntheanine®, the most respected source and the one which has been used in scientific studies. L-Theanine may promote a sense of relaxation without causing drowsiness.* It has also been found to promote healthy cellular function and reduce feelings of stress and anxiety.* Relaxation support is enhanced by the synergistic effects of the added chamomile extract.*"}' data-sheets-userformat='{"2":12796,"5":{"1":[{"1":2,"2":0,"5":{"1":2,"2":10066329}},{"1":0,"2":0,"3":3},{"1":1,"2":0,"4":1}]},"6":{"1":[{"1":2,"2":0,"5":{"1":2,"2":10066329}},{"1":0,"2":0,"3":3},{"1":1,"2":0,"4":1}]},"7":{"1":[{"1":2,"2":0,"5":{"1":2,"2":10066329}},{"1":0,"2":0,"3":3},{"1":1,"2":0,"4":1}]},"8":{"1":[{"1":2,"2":0,"5":{"1":2,"2":10066329}},{"1":0,"2":0,"3":3},{"1":1,"2":0,"4":1}]},"9":0,"10":2,"11":4,"15":"Arial","16":9}' data-mce-fragment="1">L-Theanine may promote a sense of relaxation without causing drowsiness.* It has also been found to promote healthy cellular function and reduce feelings of stress and anxiety.* Relaxation support is enhanced by the synergistic effects of the added chamomile extract.*</span></p>

<style type="text/css"><!-- td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;} --></style> <span data-sheets-userformat='{"2":771,"3":{"1":0},"4":{"1":3,"3":2},"11":0,"12":0}' data-sheets-value='{"1":2,"2":"L-Theanine, a unique amino acid derived from tea, is responsible for promoting relaxation, in part by downward modulating cortisol levels which is helpful in reducing the effects of stress.\n\nQuality: 60 Vegetarian Capsules"}'>L-Theanine, a unique amino acid derived from tea, is responsible for promoting relaxation, in part by downward modulating cortisol levels which is helpful in reducing the effects of stress.<br><br>Quality: 60 Vegetarian Capsules</span>

<p><span data-mce-fragment="1">The active components of Ginkgo biloba enhance the flow of oxygen and blood to the brain and promote transmission of nerve impulses, supporting mental acuity. Ginkgo biloba offers nutritional support to the vascular system by sustaining the strength and elasticity of blood vessels and capillaries. This quality product features 120mg of standardized Ginkgo biloba leaf extract 50:1 standardized to 24% flavoneglycosides, 6% terpene lactones and 0.8% ginkgolide B.</span></p> <p><span data-mce-fragment="1">Qty: 50 Capsules</span></p>

<style type="text/css"><!-- td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;} --></style> <span data-sheets-userformat='{"2":771,"3":{"1":0},"4":{"1":3,"3":2},"11":0,"12":0}' data-sheets-value='{"1":2,"2":"Curcumin has a long history of use for maintaining a healthy inflammatory response. It also appears to provide important antioxidant defense. Furthermore, it supports the body’s natural detoxification system and helps maintain healthy hepatic function. Curcumin C3 Complex has been the subject of many clinical studies and is the only turmeric chosen by the National Cancer Institute for clinical studies.\n\nQuantity: 60 Vegetarian Capsules"}'>Curcumin has a long history of use for maintaining a healthy inflammatory response. It also appears to provide important antioxidant defense. Furthermore, it supports the body’s natural detoxification system and helps maintain healthy hepatic function. Curcumin C3 Complex has been the subject of many clinical studies and is the only turmeric chosen by the National Cancer Institute for clinical studies.<br><br>Quantity: 60 Vegetarian Capsules</span>

<style type="text/css"><!-- td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;} --></style> <span data-sheets-userformat='{"2":771,"3":{"1":0},"4":{"1":3,"3":2},"11":0,"12":0}' data-sheets-value='{"1":2,"2":"Co-Enzyme Q10 softgels contain pure co-enzyme Q10 (ubiquinone). Co-enzyme Q10 is solubilized in a base of rice bran oil and vitamin E to enhance absorption of coenzyme Q10.\n\nQuantity: 30 Softgels"}'>Co-Enzyme Q10 softgels contain pure co-enzyme Q10 (ubiquinone). Co-enzyme Q10 is solubilized in a base of rice bran oil and vitamin E to enhance absorption of coenzyme Q10.<br><br>Quantity: 30 Softgels</span>

<style type="text/css"><!-- td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;} --></style> <span data-sheets-userformat='{"2":771,"3":{"1":0},"4":{"1":3,"3":2},"11":0,"12":0}' data-sheets-value='{"1":2,"2":"Black cohosh is well known for promoting comfort during menopause. Black cohosh functions by maintaining healthy levels of luteinizing hormone (LH), allowing for optimal comfort and physical well-being. The herb also exhibits mild estrogenic activity by binding to estrogen receptors. Black Cohosh Plus provides 40mg of standardized extract of the root and rhizome of the black cohosh plant. Each capsule is standardized to 2.5% triterpene glycosides and includes Chasteberry Fruit Powder and Dong Quai Root Powder.\n\nQuantity: 120 Capsules"}'>Black cohosh is well known for promoting comfort during menopause. Black cohosh functions by maintaining healthy levels of luteinizing hormone (LH), allowing for optimal comfort and physical well-being. The herb also exhibits mild estrogenic activity by binding to estrogen receptors. Black Cohosh Plus provides 40mg of standardized extract of the root and rhizome of the black cohosh plant. Each capsule is standardized to 2.5% triterpene glycosides and includes Chasteberry Fruit Powder and Dong Quai Root Powder.<br><br>Quantity: 120 Capsules</span>

<style type="text/css"><!-- td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;} --></style> <span data-sheets-userformat='{"2":771,"3":{"1":0},"4":{"1":3,"3":2},"11":0,"12":0}' data-sheets-value='{"1":2,"2":"Alpha Lipoic Acid capsules contain 300 mg of pure alpha-lipoic acid. Alpha-lipoic acid is a non-vitamin coenzyme that carries out important metabolic and antioxidant functions in the body.\n\nQuantity: 60 Capsules"}'>Alpha Lipoic Acid capsules contain 300 mg of pure alpha-lipoic acid. Alpha-lipoic acid is a non-vitamin coenzyme that carries out important metabolic and antioxidant functions in the body.<br><br>Quantity: 60 Capsules</span>