Seizures and PTSD, I love to help my patients!

Every day I am approached by wonderful patients who are looking for unique solutions to their problems, and believe me……I love to help anyone I can! It feels great to help those in need. Those that know me also know that I don’t believe that anything happens by chance. I believe that all things are gifted providentially by God.

David J. Miller, RPh, PhD, FIACP, FACA Owner and Chief Formulation Scientist

David J. Miller, RPh, PhD, FIACP, FACA
Owner and Chief Formulation Scientist

Last week, the mother of one of my pediatric patients came to me. This poor little patient suffers from almost continuous seizures. The doctors have tried all of the traditional therapies and just keep changing up the therapies trying to find something to stop her seizures. I left the counter after talking to her mom and…….Boom….in my inbox was an article about treatment of refractory seizures with midazolam nasal spray. This study examined 75 patients with epilepsy. Administration of intranasal midazolam significantly decreased the number of seizures in the patients and increased the seizure-free interval from 2.4 hours in patients not using midazolam nasal spray to almost 6 hours following treatment with the nasal spray. Worth a try, nothing else has worked, why not?

Another patient last week stated that someone in their family suffers from post-traumatic stress disorder (PTSD). Again, as soon as I left my meeting, I found an article in my inbox where ketamine may benefit children with PTSD. This followed a case study of a 7 year old boy. The authors stated that the child demonstrated sustained remission from symptoms for up to 13 days. My patient’s family member is an adult military veteran, so I started researching the use of ketamine in adults to treat PTSD. Behold a 2014 article in JAMA Psychiatry held the answer. These researchers found that after administration of midazolam, there was a significant decrease in PTSD symptoms. In addition, ketamine administration was also associated with a reduction in depressive symptoms associated with PTSD. The authors concluded that ketamine was generally well tolerated without substantial negative effects.

My team and I love a good challenge, especially when we can have a positive impact on our patients’ health and the lives of their families. If you have a medical need that is currently challenging you or your physician, ask about our five-star consulting program and let us help you.

1. http://www.neurologyadvisor.com/epilepsy/epilespy-seizure-intranasal-midazolam-treatment/article, http://bit.ly/1U6DRyp
2. http://www.neurologyadvisor.com/neurobehavioral-disorders/post-traumatic-stress-disorder-ptsd-ketamine/article, http://bit.ly/1U6EbgK
3.  Adriana Feder, MD; Michael K. Parides, PhD; James W. Murrough, MD; Andrew M. Perez, MD; Julia E. Morgan, BA; Shireen Saxena, MScPH; Katherine Kirkwood, MS; Marije aan het Rot, PhD; Kyle A. B. Lapidus, MD, PhD;Le-Ben Wan, MD, PhD; Dan Iosifescu, MD; Dennis S. Charney, MD Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder A Randomized Clinical Trial. JAMA Psychiatry. 2014;71(6):681-688
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